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Relation between phalangeal bone mineral density and radiographic knee osteoarthritis: a cross-sectional study
- Source :
- BMC Musculoskeletal Disorders
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Major reports have suggested that bone mineral density (BMD) is higher in patients with osteoarthritis (OA), while other studies do not agree. Our aim was to examine the cross-sectional association between phalangeal BMD and radiographic knee OA. Methods A total of 2855 participants were included in this study. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade ≥ 2 in at least one leg. BMD scans of the middle phalanges of the second, third and fourth digits of the nondominant hand were performed with a compact radiographic absorptiometry system (Alara MetriScan®). A multivariable logistic analysis model was applied to test the relation between phalangeal BMD with radiographic knee OA, the presence of knee osteophytes (OSTs), and knee joint space narrowing (JSN) after adjusting for a number of potential confounding factors. Results The multivariable-adjusted odds ratios with 95 % confidence intervals [ORs (95 % CI)] of radiographic knee OA across phalangeal BMDs were 1.08 (95 % CI 0.89–1.32) and 0.62 (95 % CI 0.45–0.86), respectively. The P for trend was 0.09. For the female population, the multivariable-adjusted ORs (95 % CI) of radiographic knee OA across phalangeal BMD were 1.01 (95 % CI 0.73–1.37) and 0.58 (95 % CI 0.38 − 0.87), respectively. The P for trend was 0.02. This positive finding, however, did not exist in the male subgroup. There was a significantly lower prevalence of OST in the osteoporosis (OP) group than in the normal group (OR = 0.59, 95 % CI 0.40–0.88; P for trend was 0.01). In contrast, the prevalence of JSN was significantly higher in the osteopenia group (OR = 1.22, 95 % CI 1.00–1.48) and the OP group (OR = 1.35, 95 % CI 1.00–1.84) than in the normal group. The P for trend was 0.02. Conclusions This study observed lower odds for the presence of radiographic knee OA and OST in OP patients than in normal subjects. The prevalence of JSN was higher in the osteopenia and OP groups than in normal subjects. Electronic supplementary material The online version of this article (doi:10.1186/s12891-016-0918-x) contains supplementary material, which is available to authorized users.
- Subjects :
- Adult
Male
musculoskeletal diseases
medicine.medical_specialty
Cross-sectional study
Osteoporosis
Osteoarthritis
Knee Joint
Cohort Studies
Finger Phalanges
03 medical and health sciences
0302 clinical medicine
Rheumatology
Bone Density
Internal medicine
Bone mineral density
medicine
Humans
Knee
Orthopedics and Sports Medicine
030212 general & internal medicine
Aged
030203 arthritis & rheumatology
Bone mineral
business.industry
Odds ratio
Middle Aged
Osteoarthritis, Knee
musculoskeletal system
medicine.disease
Confidence interval
Radiography
Osteopenia
Phalangeal
Cross-Sectional Studies
Physical therapy
Female
Kellgren–Lawrence grade
business
Research Article
Subjects
Details
- ISSN :
- 14712474
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....8d550ea2d0b87a30050e8e9c3b4ce21c