Back to Search Start Over

Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents

Authors :
Buthina A. Al-Oudat
Nizar A. Al-Shar'i
Qosay A. Al‑Balas
Suaad A. Audat
Mohammad A.Y. Alqudah
Ali H. Hamzah
Ramez W. Hallak
Mel Bedi
Amanda Bryant-Friedrich
Source :
Bioorganic Chemistry. 120:105657
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

In a previous report, we described the discovery of (E)-5-((8-hydroxyquinolin-5-yl)diazenyl)-2-methylbenzenesulfonamide as a potent inhibitor of GLO-I enzyme with IC

Subjects

Subjects :
Molecular Docking Simulation
Structure-Activity Relationship
Molecular Structure
Organic Chemistry
Drug Discovery
Lactoylglutathione Lyase
Antineoplastic Agents
Enzyme Inhibitors
Molecular Biology
Biochemistry

Details

ISSN :
00452068
Volume :
120
Database :
OpenAIRE
Journal :
Bioorganic Chemistry
Accession number :
edsair.doi.dedup.....8d4641e264343608203e0d507240e9cd
Full Text :
https://doi.org/10.1016/j.bioorg.2022.105657
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details