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Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
- Source :
- Nature Communications, 1, Nature Communications, 1:145. Nature Publishing Group, Nature Communications, Nature Communications, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩, Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkänen, J P, Van Den Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, Van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Penttilä, M, Pronk, J T, Reuss, M, Salusjärvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H, De Winde, J, Petranovic, D, Oliver, S G, Workman, C T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, no. 9, 145 . https://doi.org/10.1038/ncomms1150, Nature Communications, Nature Publishing Group, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩, Nature Communications, 1. Nature Publishing Group, Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkanen, J-P, van der Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Pentilla, M, Pronk, J T, Reuss, M, Salusjarvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H V, de Winde, J H, Petranovi, D, Oliver, S G, Workman, T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, 145 . https://doi.org/10.1038/ncomms1150
- Publication Year :
- 2010
-
Abstract
- The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in the production of fuels, chemicals, food ingredients and pharmaceuticals. With the current focus on biofuels and sustainability, there is much interest in harnessing this species as a general cell factory. In this study, we characterized two yeast strains, under two standard growth conditions. We ensured the high quality of the experimental data by evaluating a wide range of sampling and analytical techniques. Here we show significant differences in the maximum specific growth rate and biomass yield between the two strains. On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism. © 2010 Macmillan Publishers Limited. All rights reserved.
- Subjects :
- Systems biology
Saccharomyces cerevisiae
ved/biology.organism_classification_rank.species
General Physics and Astronomy
Biomedical Innovation
Computational biology
Biology
Genome
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Metabolomics
Life
Model organism
030304 developmental biology
2. Zero hunger
0303 health sciences
Multidisciplinary
030306 microbiology
business.industry
ved/biology
Systems Biology
Experimental data
General Chemistry
biology.organism_classification
Phenotype
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
Yeast
Biotechnology
MSB - Microbiology and Systems Biology
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
EELS - Earth, Environmental and Life Sciences
business
Healthy Living
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, 1, Nature Communications, 1:145. Nature Publishing Group, Nature Communications, Nature Communications, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩, Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkänen, J P, Van Den Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, Van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Penttilä, M, Pronk, J T, Reuss, M, Salusjärvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H, De Winde, J, Petranovic, D, Oliver, S G, Workman, C T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, no. 9, 145 . https://doi.org/10.1038/ncomms1150, Nature Communications, Nature Publishing Group, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩, Nature Communications, 1. Nature Publishing Group, Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkanen, J-P, van der Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Pentilla, M, Pronk, J T, Reuss, M, Salusjarvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H V, de Winde, J H, Petranovi, D, Oliver, S G, Workman, T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, 145 . https://doi.org/10.1038/ncomms1150
- Accession number :
- edsair.doi.dedup.....8d45218838b5882bcd4b8382d3e90bac
- Full Text :
- https://doi.org/10.1038/ncomms1150⟩