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Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium
- Source :
- European journal of epidemiology, vol 33, iss 10
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I2 = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.
- Subjects :
- Parents
Male
Epidemiology
Reproductive health and childbirth
Acute lymphoblastic leukemia
0302 clinical medicine
Risk Factors
Pregnancy
030212 general & internal medicine
Child
Cancer
Pediatric
education.field_of_study
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Case-control
Child, Preschool
Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
Public Health and Health Services
Female
Case–control
Maternal Age
Pediatric Research Initiative
medicine.medical_specialty
Childhood leukemia
Pediatric Cancer
Childhood Leukemia
Offspring
Population
Article
Paternal Age
03 medical and health sciences
Rare Diseases
Clinical Research
medicine
Humans
Advanced maternal age
Risk factor
Preschool
education
Childhood Acute Lymphoblastic Leukemia
Maternal age
business.industry
Prevention
Infant, Newborn
Infant
Odds ratio
Newborn
medicine.disease
Childhood
Case-Control Studies
business
Demography
Subjects
Details
- ISSN :
- 15737284 and 03932990
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- European Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....8d402d0e0c09ea842d60bc56b0fa8e08
- Full Text :
- https://doi.org/10.1007/s10654-018-0402-z