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Validity of reported indicators of pesticide exposure and relevance for cytotoxic and genotoxic effects on buccal cells
- Source :
- Mutagenesis. 34:147-152
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Higher rates of nuclear anomalies in buccal cells of coffee workers exposed to pesticides in comparison to their unexposed peers were detected in our field study. Here, we extend our findings by examining other exposure indicators in this sample. Occupational exposure of 38 exposed and 33 non-exposed farmworkers was assessed as exposure days in the last month (0-25 days) and as years of exposure (0-47 years). Genotoxic and cytotoxic markers in buccal cells were analysed following standard procedures for buccal micronucleus cytome assay. Both exposure markers were associated with a higher frequency of nuclear anomalies with odds ratios more than 1. After restricting the analysis to the exposed workers only, this association remained only with the marker of recent exposure. In a secondary analysis also environmental exposure defined as proximity of the home to the nearest sprayed field (distance
- Subjects :
- Adult
Male
Health, Toxicology and Mutagenesis
Buccal swab
Physiology
Toxicology
medicine.disease_cause
03 medical and health sciences
Occupational Exposure
Genetics
medicine
Humans
Pesticides
Micronuclei, Chromosome-Defective
Genetics (clinical)
Demography
030304 developmental biology
0303 health sciences
Farmers
Micronucleus Tests
Pesticide residue
business.industry
Confounding
Mouth Mucosa
030311 toxicology
Buccal administration
Environmental exposure
Odds ratio
Middle Aged
Chromatin
Micronucleus
business
Genotoxicity
DNA Damage
Environmental Monitoring
Subjects
Details
- ISSN :
- 14643804 and 02678357
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Mutagenesis
- Accession number :
- edsair.doi.dedup.....8d394665e5c4e8cad7d773798b63d354
- Full Text :
- https://doi.org/10.1093/mutage/gey043