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Validity of reported indicators of pesticide exposure and relevance for cytotoxic and genotoxic effects on buccal cells

Authors :
Abdul Wali Khan
Michael Poteser
Hanns Moshammer
Michael Kundi
Hans-Peter Hutter
Peter Wallner
Source :
Mutagenesis. 34:147-152
Publication Year :
2018
Publisher :
Oxford University Press (OUP), 2018.

Abstract

Higher rates of nuclear anomalies in buccal cells of coffee workers exposed to pesticides in comparison to their unexposed peers were detected in our field study. Here, we extend our findings by examining other exposure indicators in this sample. Occupational exposure of 38 exposed and 33 non-exposed farmworkers was assessed as exposure days in the last month (0-25 days) and as years of exposure (0-47 years). Genotoxic and cytotoxic markers in buccal cells were analysed following standard procedures for buccal micronucleus cytome assay. Both exposure markers were associated with a higher frequency of nuclear anomalies with odds ratios more than 1. After restricting the analysis to the exposed workers only, this association remained only with the marker of recent exposure. In a secondary analysis also environmental exposure defined as proximity of the home to the nearest sprayed field (distance

Details

ISSN :
14643804 and 02678357
Volume :
34
Database :
OpenAIRE
Journal :
Mutagenesis
Accession number :
edsair.doi.dedup.....8d394665e5c4e8cad7d773798b63d354
Full Text :
https://doi.org/10.1093/mutage/gey043