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Decreased Peritoneal Tissue Plasminogen Activator During Prolonged Laparoscopic Surgery
- Source :
- Journal of surgical research, 151(1), 89-93. Academic Press Inc.
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Background Peritoneal fibrinolysis is crucial in the peritoneal healing processes and subsequent adhesion formation. During conventional surgery, the peritoneal fibrinolytic system is rapidly disturbed. Short-term laparoscopy does not seem to affect peritoneal fibrinolysis. The aim of the present study was to assess the effect of prolonged laparoscopic surgery on peritoneal fibrinolysis. Methods Twelve consecutive patients undergoing laparoscopic gastric bypass surgery for morbid obesity were included in the study. During the procedure, biopsies of the parietal peritoneum were taken at the start of the procedure and each 45 min afterward. Tissue samples were homogenized and tissue-type plasminogen activator (tPA) antigen, tPA activity, urokinase-type PA antigen, and plasminogen activating inhibitors type 1 antigen were measured using commercial assay techniques. Results Both tPA antigen and its activity progressively decreased during the procedure, reaching significant levels after 90 min of surgery. The levels of uPA antigen and plasminogen activating inhibitors antigen did not significantly change throughout the procedure. Conclusions As for conventional surgery, prolonged laparoscopic surgery causes a decreased fibrinolytic activity in the peritoneum due to decreased tPA levels.
- Subjects :
- Adult
Male
Laparoscopic surgery
medicine.medical_specialty
Time Factors
Biopsy
medicine.medical_treatment
Gastric Bypass
Urology
Adhesion (medicine)
Tissue Adhesions
Tissue plasminogen activator
Peritoneum
Plasminogen Activator Inhibitor 1
Fibrinolysis
medicine
Humans
Retrospective Studies
Wound Healing
medicine.diagnostic_test
business.industry
T-plasminogen activator
Middle Aged
medicine.disease
Urokinase-Type Plasminogen Activator
Obesity, Morbid
Surgery
medicine.anatomical_structure
Tissue Plasminogen Activator
Female
Laparoscopy
business
Plasminogen activator
medicine.drug
Subjects
Details
- ISSN :
- 00224804
- Volume :
- 151
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Research
- Accession number :
- edsair.doi.dedup.....8d348b0eb8d4f30265f12ae82c85c52f