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Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine
- Source :
- Schizophrenia Research. 56:11-17
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Atypical neuroleptics share a common feature, showing higher affinity for 5-HT2 receptors than for D2 dopamine receptors, but show considerable differences in their clinical and pharmacological properties. In clinical doses, they occupy serotonergic receptors near saturation, but show considerable differences regarding the D2 receptor occupancies, with clozapine showing the lowest degree of occupation. We assessed serotonergic and dopaminergic receptor responsivities in two groups of male schizophrenic patients, one treated with the atypical neuroleptic clozapine (14 patients, doses 200–600 mg/d) and the other treated with olanzapine (11 patients, doses 10–30 mg/d). We measured the prolactin responses to the acute administration of a serotonergic drug, clomipramine, and a dopaminergic one, haloperidol. Tests were first performed in the drug-free state, and were repeated after the patients had been treated with stable doses of either drug for six weeks. Clomipramine administration induced significant increases of prolactin in the drug-free state. These responses were eliminated after treatment of the patients with either drug, thereby indicating a high 5-HT receptor occupancy by both clozapine and olanzapine. The prolactin responses to haloperidol were not altered after treatment with clozapine, but were significantly reduced after the olanzapine treatment. The baseline prolactin levels were not influenced by clozapine treatment, and were moderately but significantly increased after treatment with olanzapine. The results indicate that there is a difference between the two drugs in their capacity to block dopamine receptors at the hypothalamus–pituitary level, and match the results obtained by SPECT receptor binding studies for striatal dopamine receptors.
- Subjects :
- Adult
Male
Olanzapine
Hypothalamo-Hypophyseal System
Clomipramine
medicine.medical_specialty
Benzodiazepines
Internal medicine
Dopamine receptor D2
medicine
Haloperidol
Humans
Clozapine
Biological Psychiatry
Psychiatric Status Rating Scales
Receptors, Dopamine D2
business.industry
Dopaminergic
Dopamine antagonist
Pirenzepine
Middle Aged
Prolactin
Psychiatry and Mental health
Treatment Outcome
Endocrinology
Dopamine receptor
Receptors, Serotonin
Chronic Disease
Schizophrenia
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 09209964
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Research
- Accession number :
- edsair.doi.dedup.....8d2f98e51a7f5c0607aeb2b5a32eefc3