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Global N-acetylaspartate concentration in benign and non-benign multiple sclerosis patients of long disease duration
- Source :
- European Journal of Radiology. 82:e848-e852
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- To examine whether clinically benign multiple sclerosis patients (BMS) show similar losses of their global N-acetylaspartate (NAA) neuronal marker relative to more clinically disabled patients of similar disease duration.The whole-brain NAA concentration (WBNAA) was acquired with whole-head non-localizing proton MR spectroscopy. Fractional brain parenchymal volume (fBPV), T2 and T1 lesion loads, were obtained from the MRI in: (i) 24 BMS patients: 23.1 ± 7.2 years disease duration, median Expanded Disability Status Scale (EDSS) score of 2.0 (range: 0-3); (ii) 26 non-benign MS patients (non-BMS), 24.5 ± 7.4 years disease duration, median EDSS of 4.0 (range: 3.5-6.5); (iii) 15 healthy controls.Controls' 12.4 ± 2.3mM WBNAA was significantly higher than the BMS's and non-BMS's 10.5 ± 2.4 and 9.9 ± 2.1mM (both p0.02), but the difference between the patients' groups was not (p0.4). Likewise, the controls' 81.2 ± 4.5% fBPV exceeded the BMS and non-BMS's 77.0 ± 5.8% and 76.3 ± 8.6% (p0.03), which were also not different from one another (p0.7). BMS patients' T1-hypointense lesion load, 2.1 ± 2.2 cm(3), was not significantly different than the non-BMS's 4.1 ± 5.4 cm(3) (p0.08) and T2-hyperintense loads: 6.0 ± 5.7 cm(3) and 8.7 ± 7.8 cm(3), were also not different (p0.1).WBNAA differentiates normal controls from MS patients but does not distinguish BMS from more disabled MS patients of similar disease duration. Nevertheless, all MS patients who remain RR for 15+ years suffered WBNAA loss similar to the average RR MS population at fourfold shorter disease duration suggesting relative global neuronal sparing or leveling-off of the neurodegeneration rate.
- Subjects :
- Adult
Male
In vivo magnetic resonance spectroscopy
Pathology
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Population
Sensitivity and Specificity
Severity of Illness Index
Gastroenterology
Article
Diagnosis, Differential
Lesion
Internal medicine
Severity of illness
medicine
Humans
Radiology, Nuclear Medicine and imaging
Longitudinal Studies
education
Brain Chemistry
Aspartic Acid
education.field_of_study
Expanded Disability Status Scale
medicine.diagnostic_test
business.industry
Multiple sclerosis
Reproducibility of Results
Magnetic resonance imaging
General Medicine
Multiple Sclerosis, Chronic Progressive
medicine.disease
Magnetic Resonance Imaging
Female
Protons
Differential diagnosis
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 0720048X
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- European Journal of Radiology
- Accession number :
- edsair.doi.dedup.....8d2e521cdacfedfc391f045ab439b7e9
- Full Text :
- https://doi.org/10.1016/j.ejrad.2013.08.037