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Long-distance energy transfer photosensitizers arising in hybrid nanoparticles leading to fluorescence emission and singlet oxygen luminescence quenching
- Source :
- Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, Royal Society of Chemistry, 2012, 11 (5), pp.803-811. 〈10.1039/c2pp05324a〉, Photochemical & Photobiological Sciences, Photochemical & Photobiological Sciences, Royal Society of Chemistry, 2012, 11 (5), pp.803-811. ⟨10.1039/c2pp05324a⟩
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- International audience; This paper presents energy transfer occurring in small organically modified core-shell nanoparticles (core lanthanide oxide, shell polysiloxane) (diameter < 10 nm) conjugated with photosensitizers designed for photodynamic therapy applications. These nanoparticles covalently encapsulate a photosensitizing PDT drug in different concentrations. Stable dispersions of the nanoparticles were prepared and the photophysical properties of the photosensitizers were studied and compared to those of the photosensitizers in solution. Increasing the photosensitizer concentration in the nanoparticles was not found to cause any changes in the absorption properties while fluorescence and singlet oxygen quantum yields decreased. As a possible explanation, we have suggested that both long distance energy transfer such as FRET and self-quenching could occur into the nanoparticles. A simple "trend" model of this kind of energy transfer complies with results of experiments on steady state fluorescence and singlet oxygen luminescence.
- Subjects :
- Luminescence
Materials science
Siloxanes
CARRIER
Nanoparticle
02 engineering and technology
010402 general chemistry
Photochemistry
01 natural sciences
7. Clean energy
Fluorescence
PRODRUGS
PHOTODYNAMIC THERAPY
chemistry.chemical_compound
Lanthanum
Neoplasms
Fluorescence Resonance Energy Transfer
Humans
PARTICLES
Photosensitizer
Physical and Theoretical Chemistry
AGENTS
Absorption (electromagnetic radiation)
Drug Carriers
Photosensitizing Agents
Quenching (fluorescence)
Singlet Oxygen
Singlet oxygen
Oxides
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Photochemical Processes
021001 nanoscience & nanotechnology
0104 chemical sciences
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
[ PHYS.PHYS.PHYS-CHEM-PH ] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
Spectrometry, Fluorescence
[ SDV.SP ] Life Sciences [q-bio]/Pharmaceutical sciences
Förster resonance energy transfer
Energy Transfer
Models, Chemical
Photochemotherapy
chemistry
CELLS
[ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistry
Nanoparticles
[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
0210 nano-technology
Subjects
Details
- ISSN :
- 14749092 and 1474905X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Photochemical & Photobiological Sciences
- Accession number :
- edsair.doi.dedup.....8d0ece4c5e603b97b99f5b44f82d9b08