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Selection of adjuvants for vaccines targeting specific pathogens
- Source :
- Expert Review of Vaccines
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis, 2019.
-
Abstract
- Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Different pathogens have distinct characteristics, which require the host to mount an appropriate immune response against them. Adjuvants can be selected to elicit a tailor-made immune response to specific pathogens based on their unique properties. Identification of biomarkers of adjuvanticity for several candidate vaccines using omics-based technologies can unravel the mechanism of action of modern and experimental adjuvants. Expert opinion: Adjuvant technology has been revolutionized over the last two decades. In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvants that can be used in vaccines against challenging pathogens and in specific target populations.
- Subjects :
- 0301 basic medicine
Biomedical Research
Immunology
Computational biology
Review
Biology
Adaptive Immunity
03 medical and health sciences
0302 clinical medicine
Immune system
Adjuvants, Immunologic
Immunity
Component (UML)
Drug Discovery
Humans
030212 general & internal medicine
Adjuvants
Selection (genetic algorithm)
systems vaccinology
Pharmacology
Systems Biology
immunity
Immunity, Innate
3. Good health
030104 developmental biology
Vaccines, Inactivated
Vaccines, Subunit
Molecular Medicine
mechanism of action
pathogen
Subjects
Details
- Language :
- English
- ISSN :
- 17448395 and 14760584
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert Review of Vaccines
- Accession number :
- edsair.doi.dedup.....8d0e212e0ef3bb0223c5dcb10c0f0e2f