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F-18 FDG PET/CT and F-18 FLT PET/CT as predictors of outcome in patients with multiple myeloma. A pilot study
- Source :
- European Journal of Radiology. 136:109564
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- We evaluated the prognostic significance of the combined use of F-18 FDG (FDG) and F-18 FLT (FLT) PET/CT (PET/CT) in patients (pts) with multiple myeloma (MM) suspected relapse after a first line chemotherapy.twenty-eight patients (57 ± 12 years) underwent both PET/CT scans over 2-4 weeks. Patients were grouped according to imaging results (FDG+/-; FLT+/-) and the findings compared to the event free survival (EFS).five pts had FDG+; FLT+, 8 showed FDG+;FLT-, two had FDG-;FLT + and 13 presented FDG-;FLT-, mostly (87 %) of FDG+;FLT- pts had destructive lytic bone lesions. At Cox regression analysis the FDG PET/CT (HR 4.4, 95 % CI 1.3-15.4, p0.05) and FLT PET/CT (HR 5.8, 95 % CI 1.7-19.3, p0.01) were predictive of worst prognosis. The Kaplan-Meier analysis showed that FDG and FLT PET/CT independently influenced the survival. FDG-;FLT-patients had better EFS as compared to FDG+; FLT + pts and FDG-;FLT + pts, those of FDG+;FLT- group also had worsened EFS.results from the aggregate use of PET/CT FDG and FLT in MM represent a valuable prognostic indicator for identifying patients at higher risk of undue events and may help to correctly stratify the patients with suspected relapse.
- Subjects :
- Combined use
Pilot Projects
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
neoplasms
Multiple myeloma
medicine.diagnostic_test
Proportional hazards model
business.industry
General Medicine
medicine.disease
F 18 fdg pet ct
Dideoxynucleosides
carbohydrates (lipids)
Bone lesion
Positron emission tomography
Positron-Emission Tomography
030220 oncology & carcinogenesis
cardiovascular system
sense organs
Neoplasm Recurrence, Local
Radiopharmaceuticals
First line chemotherapy
Multiple Myeloma
Nuclear medicine
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 0720048X
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- European Journal of Radiology
- Accession number :
- edsair.doi.dedup.....8d02851491c100520f02694332875f28