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Aquaporin 3 Expression in Endometrioid Carcinoma of the Uterine Body Correlated With Early Stage and Lower Grade
- Source :
- Pathology & Oncology Research. 26:2247-2253
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Aquaporins (AQPs) are a family of transmembrane water channel proteins distributed in various human tissues. Recent studies revealed that AQPs play important roles in cancer biology. Few studies have documented the relationship between the prognosis, stage, and histological grade of uterine endometrioid carcinoma, with AQP expression. Hence, the present study aimed to investigate this relationship between uterine endometrioid carcinoma and AQP expression. We retrospectively reviewed records of the patients who underwent surgery for uterine body cancer between 1990 and 2010 at the National Defense Medical College Hospital, Saitama, Japan. In 241 cases of endometrioid carcinoma, we immunohistochemically examined the expression of AQP 1, 2, 3, 4, and 5, and their relationship with clinicopathological parameters and the patients’ prognosis. We investigated the relationship between the clinicopathological parameters and AQP3 expression, and found that as the FIGO stage and histological grade progressed, the percentage of AQP3 expression tends to decrease. Furthermore, we analyzed progression-free survival/overall survival (PFS/OS) using the log-rank test, and found that the AQP3-positive group had a better prognosis than AQP3-negative group (PFS: P
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Uterus
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
medicine
Carcinoma
Humans
Stage (cooking)
Neoplasm Staging
Retrospective Studies
Aquaporin 3
business.industry
Proportional hazards model
Hazard ratio
Cancer
General Medicine
Middle Aged
medicine.disease
Endometrial Neoplasms
Survival Rate
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Uterine Neoplasms
Immunohistochemistry
Female
Neoplasm Grading
business
Carcinoma, Endometrioid
Follow-Up Studies
Subjects
Details
- ISSN :
- 15322807 and 12194956
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Pathology & Oncology Research
- Accession number :
- edsair.doi.dedup.....8cf425e3dc0c0b60c0566215ac12006c