3,5-Bis(trifluoromethyl)phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety

Authors :: Jufeng, Sun
Joey I, Ambrus
Jennifer R, Baker
Cecilia C, Russell
Peter J, Cossar
Jennette A, Sakoff
Christopher J, Scarlett
Adam, McCluskey
Source :: Bioorganic & Medicinal Chemistry Letters. 61:128591
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: Virtual screening identified N-(6-((4-bromobenzyl)amino)hexyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (1) a lead compound that bound to the S100A2-p53 binding groove. S100A2 is a Ca

Subjects :: Dose-Response Relationship, Drug
Molecular Structure
Organic Chemistry
Clinical Biochemistry
Drug Evaluation, Preclinical
Pharmaceutical Science
Antineoplastic Agents
Biochemistry
Pancreatic Neoplasms
Structure-Activity Relationship
Cell Line, Tumor
Drug Discovery
Humans
Molecular Medicine
Drug Screening Assays, Antitumor
Molecular Biology
Cell Proliferation

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