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Acute Kidney Injury Increase Risk of Left Ventricular Remodeling: A Cohort of 1,573 Patients
- Source :
- Frontiers in Physiology, Frontiers in Physiology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Background: Acute kidney injury (AKI) is a common complication after coronary angiography (CAG) and associated with heart failure (HF). Left ventricular (LV) remodeling is a vital process in the progression of HF. However, few studies investigate the relationship between AKI and LV remodeling.Methods: We included consecutive patients undergoing CAG from January 2007 to December 2018 at Guangdong Provincial People’s Hospital (NCT04407936). AKI was defined as an absolute increase in serum creatinine (Scr) of ≥ 0.3mg/dl or a ≥ 50% increase in Scr from baseline within the first 48–72 h after the procedure. LV remodeling was defined as: (1) an absolute decrease in left ventricular ejection fraction (LVEF) of ≥ 10% compared to baseline, or (2) a follow-up LVEF < 40%. Univariate and multivariate logistical regressions were used to assess the association between AKI and LV remodeling.Results: Of the 1,573 patients (62.2 ± 9.7 years, female 36.7%) included in the study, 231 (14.7%) had AKI. The incidence of LV remodeling was higher in patients with AKI than in those without AKI (24.7% vs. 14.5%). After adjusting for confounding, multivariate logistic regression showed that AKI was associated with a significantly higher risk of LV remodeling [adjusted odds ratio (aOR) 1.87; 95% CI, 1.30–2.66; p < 0.001]. In addition, LV remodeling patients had higher all-cause mortality compared to non-LV remodeling patients (9.7% vs. 19.1%).Conclusion: Our data suggested that AKI is present in up to 15% of patients after CAG and that nearly a quarter of AKI patients suffered LV remodeling and AKI patients have a two-fold risk of developing LV remodeling than non-AKI patients. Our findings suggest that more active measures be taken not only to prevent AKI patient developing into LV remodeling, but to prevent patients undergoing CAG from developing AKI.
- Subjects :
- medicine.medical_specialty
Physiology
urologic and male genital diseases
chemistry.chemical_compound
Internal medicine
Physiology (medical)
medicine
QP1-981
Ventricular remodeling
Original Research
left ventricular remodeling
Creatinine
Ejection fraction
business.industry
Acute kidney injury
Odds ratio
medicine.disease
female genital diseases and pregnancy complications
acute kidney injury
chemistry
Heart failure
Cohort
incidence
Cardiology
coronary angiography
cardiac remodeling
Complication
business
Subjects
Details
- Language :
- English
- ISSN :
- 1664042X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....8ce4f2040bc4d93864f45b2a3d8fbc45
- Full Text :
- https://doi.org/10.3389/fphys.2021.744735