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Predictive value of brain MRI at term-equivalent age in extremely preterm children on neurodevelopmental outcome at school-age
- Source :
- Brain Imaging and Behavior, Brain Imaging and Behavior, 2022, 16 (2), pp.878--887. ⟨10.1007/s11682-021-00559-9⟩
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Place: United States; This study's objective was to correlate the abnormalities in brain MRIs performed at corrected-term age for minor or moderate neurocognitive disorders in children school-age born extremely premature (EPT) and without serious sequelae such as autism, cerebral palsy, mental impairment. Data were issued from a cross-sectional multicenter study (GP-Qol study, number NCT01675726). Clinical examination and psychometric assessments were performed when the children were between 7 and 10 years old during a day-long evaluation. Term-equivalent age brain MRIs on EPT were analyzed with a standardized scoring system. There were 114 children included in the study. The mean age at the time of evaluation, was 8.47 years old (± 0.70). 59% of children with at least one cognitive impairment and 53% who had a dysexecutive disorder. Only ten EPT (8.7%) presented moderate to severe white and grey matter abnormalities. These moderate to severe grey matter abnormalities were associated with at least two abnormal executive functions [OR 3.08 (95% CI 1.04-8.79), p = 0.04] and language delay [OR 3.25 (95% CI 1.03-9.80), p = 0.04]. These results remained significant in the multivariate analysis. Moderate to severe ventricular dilatation abnormalities (15%, n = 17) were associated with ideomotor dyspraxia [OR 7.49 (95% CI 1.48-35.95), p = 0.02] and remained significant in multivariate analysis [OR 11.2 (95% CI 1.45-131.4), p = 0.02]. Biparietal corrected diameters were moderate abnormal in 20% of cases (n = 23) and were associated to visuo spatial integration delay [OR 4.13 (95% CI 1.23-13.63), p = 0.02]. Cerebral MRI at term-equivalent age with scoring system analysis can provide information on long-term neuropsychological outcomes at school-age in EPTs children having no severe disability.
- Subjects :
- Pediatrics
medicine.medical_specialty
Magnetic Resonance Imaging/methods
Multivariate analysis
Language delay
Cognitive Neuroscience
Extremely preterm
School age
Physical examination
Extremely Premature
Grey matter
Cerebral palsy
Executive Function
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Child
Infant
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Neurodevelopmental outcome
medicine.diagnostic_test
business.industry
Infant, Newborn
Neuropsychology
Brain
Brain/diagnostic imaging
Newborn
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
Cross-Sectional Studies
medicine.anatomical_structure
Impairment
Neurology
Brain MRI
Infant, Extremely Premature
Autism
Neurology (clinical)
business
Neurocognitive
Subjects
Details
- ISSN :
- 19317565 and 19317557
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Brain Imaging and Behavior
- Accession number :
- edsair.doi.dedup.....8ccba7c721ded7b8db27f4fce316dceb