Back to Search
Start Over
Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity
- Source :
- PLoS medicine, Vol. 18, no.5, p. e1003648 [1-7] (2021), PLoS Medicine, PLoS medicine, 18 (5, PLoS Medicine, Vol 18, Iss 5, p e1003648 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Thrombotic thrombocytopenia mimicking heparin-induced thrombocytopenia has been observed in patients with severe Coronavirus Disease 2019 (COVID-19AU :Pleasenotethat COVID ) or after immunisation with adenoviral vector-based vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Herein, we discuss the pathogenesis of the autoimmune response to platelet factor 4 (PF4) that underlies these disorders.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- RNA viruses
Viral Diseases
Physiology
Coronaviruses
viruses
Autoimmunity
030204 cardiovascular system & hematology
Platelet Factor 4
medicine.disease_cause
Biochemistry
Epithelium
Medical Conditions
0302 clinical medicine
Animal Cells
Risk Factors
Heparin-Induced Thrombocytopenia
Immune Physiology
Medicine and Health Sciences
Medicine
Platelet
030212 general & internal medicine
skin and connective tissue diseases
Pathology and laboratory medicine
Vaccines
Immune System Proteins
Vaccination
virus diseases
Hematology
General Medicine
Medical microbiology
Body Fluids
Infectious Diseases
Blood
Perspective
Viruses
Host-Pathogen Interactions
Anatomy
Cellular Types
SARS CoV 2
Pathogens
Platelets
COVID-19 Vaccines
Infectious Disease Control
SARS coronavirus
Coronavirus disease 2019 (COVID-19)
Biochimie
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immunology
Biotechnologie
macromolecular substances
Microbiology
Risk Assessment
Antibodies
03 medical and health sciences
Virology
ChAdOx1 nCoV-19
Heparin-induced thrombocytopenia
Animals
Humans
Platelet activation
Blood Coagulation
Autoantibodies
Purpura, Thrombocytopenic, Idiopathic
Blood Cells
SARS-CoV-2
business.industry
fungi
Organisms
Viral pathogens
Biologie moléculaire
Biology and Life Sciences
Endothelial Cells
Proteins
COVID-19
Covid 19
Epithelial Cells
Viral Vaccines
Cell Biology
Platelet Activation
medicine.disease
Thrombocytopenia
Microbial pathogens
body regions
Biological Tissue
Biologie cellulaire
business
Platelet factor 4
Subjects
Details
- ISSN :
- 15491676
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- PLOS Medicine
- Accession number :
- edsair.doi.dedup.....8cb198d225390d71ad1c7b9c194c7fa5