Back to Search
Start Over
Misclassification Error-Adjusted Prevalence of Injection Drug Use Among Infective Endocarditis Hospitalizations in the United States: A Serial Cross-Sectional Analysis of the 2007-2016 National Inpatient Sample
- Source :
- Am J Epidemiol
- Publication Year :
- 2020
-
Abstract
- Administrative health databases have been used to monitor trends in infective endocarditis hospitalization related to nonprescription injection drug use (IDU) using International Classification of Diseases (ICD) code algorithms. Because no ICD code for IDU exists, drug dependence and hepatitis C virus (HCV) have been used as surrogate measures for IDU, making misclassification error (ME) a threat to the accuracy of existing estimates. In a serial cross-sectional analysis, we compared the unadjusted and ME-adjusted prevalences of IDU among 70,899 unweighted endocarditis hospitalizations in the 2007–2016 National Inpatient Sample. The unadjusted prevalence of IDU was estimated with a drug algorithm, an HCV algorithm, and a combination algorithm (drug and HCV). Bayesian latent class models were used to estimate the median IDU prevalence and 95% Bayesian credible intervals and ICD algorithm sensitivity and specificity. Sex- and age group-stratified IDU prevalences were also estimated. Compared with the misclassification-adjusted prevalence, unadjusted estimates were lower using the drug algorithm and higher using the combination algorithm. The median ME-adjusted IDU prevalence increased from 9.7% (95% Bayesian credible interval (BCI): 6.3, 14.8) in 2008 to 32.5% (95% BCI: 26.5, 38.2) in 2016. Among persons aged 18–34 years, IDU prevalence was higher in females than in males. ME adjustment in ICD-based studies of injection-related endocarditis is recommended.
- Subjects :
- Adult
Male
Adolescent
Epidemiology
Cross-sectional study
Combination algorithm
Sample (statistics)
01 natural sciences
Injection drug use
03 medical and health sciences
Young Adult
0302 clinical medicine
Bacterial endocarditis
mental disorders
medicine
Prevalence
Endocarditis
Humans
030212 general & internal medicine
Registries
0101 mathematics
Substance Abuse, Intravenous
Retrospective Studies
Inpatients
business.industry
010102 general mathematics
virus diseases
Original Contribution
Middle Aged
medicine.disease
Misclassification error
United States
Hospitalization
Cross-Sectional Studies
Infective endocarditis
Female
business
Algorithms
Demography
Follow-Up Studies
Subjects
Details
- ISSN :
- 14766256
- Volume :
- 190
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American journal of epidemiology
- Accession number :
- edsair.doi.dedup.....8caf062c3de3dddae8fa27614ed5469e