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Predictive value of low interleukin-33 in critically ill patients
- Source :
- Cytokine. 103:109-113
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating levels of its "decoy" receptor soluble ST2 (sST2) are associated with outcome in critically ill patients. The aim of the present study was to investigate whether circulating IL-33 is associated with 30-day mortality in patients admitted to a medical ICU. In this prospective, observational study, both IL-33 and sST2 levels were assessed in 223 consecutive patients at ICU admission using specific enzyme-linked immunosorbent assays (ELISAs). During the 30-day follow-up, 58 patients (26%) died. Circulating IL-33 was detectable in 166 patients and in 57 patients, serum IL-33 was below the detection limit. Both detectable IL-33 and sST2 below the median were strong predictors of survival in critically ill patients independent of acute physiology and chronic health evaluation II (APACHE II) score. IL-33 and sST2 predicted risk independent from each other. Patients with both, non-detectable levels of IL-33 and sST2 levels above the median, showed a dramatically increased mortality risk (HR 6.9 95% CI 3.0-16.2; p
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Critical Illness
Immunology
030204 cardiovascular system & hematology
Biochemistry
Sepsis
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Immunology and Allergy
Prospective Studies
Mortality
Intensive care medicine
Molecular Biology
Aged
APACHE II
business.industry
Critically ill
Mortality rate
Interleukin
Hematology
Interleukin-33
medicine.disease
Interleukin-1 Receptor-Like 1 Protein
Predictive value
Interleukin 33
Intensive Care Units
030104 developmental biology
Female
Observational study
business
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....8cab83811a9c2c1bdcf1ce7a648d8445