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Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome
- Source :
- Current Problems in Cancer. 43:123-129
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at the time of diagnosis of breast cancer is associated with metastasis, recurrence, and death in breast cancer patients from Malwa region of Punjab where breast cancer is widely feared.Two hundred and forty-two breast cancer patients and 242 age and sex matched controls were included in the study. CRP levels were estimated using fully automated bio analyzer Erba200. Follow up interviews were conducted at an interval of 3, 6, 9, 12, 15, 18, 21, 24, and 27 months to determine the outcome among breast cancer patients.Elevated levels of CRP were found among the diseased in comparison with controls (P0.0001). Higher CRP levels associated significantly with poor outcome including metastasis and recurrence among breast cancer patients [P = 0.03; 95% confidence interval; odds ratio: 2.954 (0.9125-9.561)].Elevated levels of CRP associated significantly with increased risk of breast cancer and poor outcome. CRP estimation may be a simple and inexpensive tool for the risk assessment and outcome of the disease in Malwa region of Punjab where incidence of breast cancer is reported to be very high.
- Subjects :
- Adult
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
India
Breast Neoplasms
Inflammation
Disease
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Humans
Medicine
Neoplasm Metastasis
Aged
biology
business.industry
Incidence (epidemiology)
Carcinoma
C-reactive protein
Middle Aged
medicine.disease
C-Reactive Protein
030104 developmental biology
Increased risk
030220 oncology & carcinogenesis
biology.protein
Female
Neoplasm Recurrence, Local
medicine.symptom
business
Risk assessment
Subjects
Details
- ISSN :
- 01470272
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Current Problems in Cancer
- Accession number :
- edsair.doi.dedup.....8cab1216580acbf617aafb56f57bacbc