Back to Search
Start Over
Effect of body mass index on vertebral and hip fractures in older people and differences according to sex: a retrospective Japanese cohort study
- Source :
- BMJ Open, BMJ Open, Vol 11, Iss 11 (2021)
- Publication Year :
- 2021
-
Abstract
- ObjectivesThe purpose of this study was to investigate the incidence of vertebral and hip fractures in the older people and to clarify the relationship between these fractures and body mass index (BMI) along with the impact of sex differences.DesignThis was a retrospective cohort study.SettingWe used administrative claims data between April 2010 and March 2018.ParticipantsOlder people aged ≥75 years who underwent health examinations in 2010 and were living in the Fukuoka Prefecture, Japan were included in the study. A total of 24 691 participants were included; the mean age was 79.4±4.3 years, 10 853 males and 13 838 females, and an the mean duration of observation was 6.9±1.6 years.Primary and secondary outcome measuresWe estimated the incidence of vertebral and hip fractures by BMI category (underweight: 2, normal weight: 18.5–24.9 kg/m2, overweight and obese: ≥25.0 kg/m2) using a Kaplan-Meier curve in males and females and determined fracture risk by sex using Cox proportional hazards regression analyses.ResultsThe incidence of vertebral and hip fractures was 16.8% and 6.5%, respectively. The cumulative incidence of vertebral and hip fracture at the last observation (8 years) in each BMI groups (underweight/normal weight/overweight and obese) estimated using the Kaplan-Meier curve was 14.7%/10.4%/9.0% in males and 24.9%/23.0%/21.9% in females, and 6.3%/2.9%/2.4% in males and 14.1%/9.0%/8.1% in females, respectively, and both fractures were significantly higher in underweight groups regardless of sex. Multivariable Cox proportional hazards models showed that underweight was a significant risk factor only in males for vertebral fractures and in both males and females for hip fractures.ConclusionUnderweight was associated with fractures in the ageing population, but there was a sex difference in the effect for vertebral fractures.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Overweight
adult orthopaedics
Body Mass Index
Cohort Studies
Japan
Risk Factors
medicine
Humans
Cumulative incidence
Aged
Retrospective Studies
Aged, 80 and over
Hip fracture
business.industry
Hip Fractures
Incidence (epidemiology)
Incidence
Retrospective cohort study
General Medicine
medicine.disease
Medicine
Female
epidemiology
Public Health
Underweight
medicine.symptom
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.doi.dedup.....8ca4655769bfc058ac835c08ce279008