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Venous thrombosis in children and adolescents with Hodgkin lymphoma in Sweden
- Source :
- Thrombosis Research. 152:64-68
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Introduction Pediatric patients with Hodgkin lymphoma (HL) have several risk factors for venous thromboembolism (VTE). Although these patients are occasionally treated with thromboprophylaxis, no guidelines are implemented in Sweden. Scarce data from adult patients indicate an increased risk of VTE, but pediatric data is largely missing. Given the favorable overall survival of HL, there should reasonably be more focus on preventing complications. Materials and methods We conducted a retrospective cohort study, including all patients registered in the Childhood Cancer Registry under the age of 18 years diagnosed with HL between January 2005 and December 2015 in Sweden. Results Data was retrieved from the medical records of all 163 patients (100%) at six Swedish pediatric cancer centers. The incidence of VTE was 7.7% (symptomatic VTE 3.9%). The median follow-up was 3.4 years (range 0.3–10.5). Only five patients (3.1%) were treated with thromboprophylaxis. All VTE events occurred in the older age category (11–17 years) and all but one (92.7%) had a mediastinal mass. While the VTE did not significantly affect the treatment of HL, it caused increased morbidity and 2/12 developed a post-thrombotic syndrome. No significant risk factors for VTE were identified. Conclusions VTE is a relatively common complication of HL and its treatment, causing increased acute and long-term morbidity. However, due to limited number of events we could not demonstrate risk-factors for VTE that would identify patients who might benefit from thromboprophylaxis.
- Subjects :
- medicine.medical_specialty
Adolescent
medicine.drug_class
Low molecular weight heparin
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
cardiovascular diseases
Child
Retrospective Studies
Sweden
Venous Thrombosis
Childhood Cancer Registry
business.industry
Incidence
Incidence (epidemiology)
Medical record
Anticoagulants
Retrospective cohort study
Hematology
Heparin, Low-Molecular-Weight
equipment and supplies
medicine.disease
Hodgkin Disease
Pediatric cancer
Surgery
Pulmonary embolism
Venous thrombosis
030220 oncology & carcinogenesis
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Thrombosis Research
- Accession number :
- edsair.doi.dedup.....8ca1d7820b5e75cb5b5506cb0775c60d