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β-Homo-amino Acid Scan of Angiotensin IV
- Source :
- Journal of Medicinal Chemistry, Journal of Medicinal Chemistry, American Chemical Society, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩, Journal of Medicinal Chemistry, 2008, 51 ((7)), pp.2291-6. ⟨10.1021/jm701490g⟩
- Publication Year :
- 2008
- Publisher :
- American Chemical Society (ACS), 2008.
-
Abstract
- International audience; Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.
- Subjects :
- Antigens, CD13
Peptide
CHO Cells
CD13 Antigens
Aminopeptidases
Aminopeptidase
Receptor, Angiotensin, Type 1
Cell Line
Structure-Activity Relationship
03 medical and health sciences
chemistry.chemical_compound
Cricetulus
0302 clinical medicine
Cricetinae
Drug Discovery
Peptide synthesis
Animals
Humans
Amino Acids
Enzyme Inhibitors
Beta (finance)
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Binding Sites
Angiotensin II receptor type 1
Dose-Response Relationship, Drug
Molecular Structure
biology
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Chemistry
Research Support, Non-U.S. Gov't
Angiotensin II
Cell Membrane
3. Good health
Amino acid
Enzyme Activation
Amino Acid Substitution
Biochemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....8c9c11c2cc7ebd3a17c01cfe5de6e89c