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Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems
- Source :
- Journal of computational neuroscience. 2(1)
- Publication Year :
- 1995
-
Abstract
- In a computational model of the bursting neuron R15, we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of serotonin (5-HT) or dopamine (DA). The model was also sufficient to simulate the responses of the neuron to extrinsic current pulses and the ways in which those responses were altered by 5-HT or DA. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. It is also necessary to take into account the indirect effects of these agents on other unmodulated ion channels. These indirect effects occur through the dynamic interactions of voltage-dependent and calcium-dependent processes.
- Subjects :
- Serotonin
Patch-Clamp Techniques
Cognitive Neuroscience
Dopamine
Models, Neurological
Endogeny
Sodium Channels
Membrane Potentials
Cellular and Molecular Neuroscience
Bursting
Serotonin Agents
Aplysia
medicine
Animals
Ion channel
Neurons
biology
Chemistry
Cell Membrane
biology.organism_classification
Calcium dependent
Sensory Systems
Electrophysiology
medicine.anatomical_structure
Nonlinear Dynamics
Second messenger system
Calcium
Neuron
Calcium Channels
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 09295313
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of computational neuroscience
- Accession number :
- edsair.doi.dedup.....8c95c0de7ec77b9efec1dcf3da139f47