Back to Search
Start Over
Insertional polymorphism of endogenous retrovirus HERV-K115 in schizophrenia
- Source :
- Neuroscience letters. 408(3)
- Publication Year :
- 2006
-
Abstract
- Retroviruses are implicated in the pathogenesis of schizophrenia. Human endogenous retrovirus type K115 (HERV-K115) is a full-length, potentially transcriptional retrovirus and is also polymorphic. We investigated the frequency of HERV-K115 in Japanese schizophrenia patients and healthy controls. No difference was found in the frequency between patients and controls (8.4% versus 9.4%, respectively). However, a marginal difference was observed in age at onset between the HERV-K positive and negative patients ( p = 0.057). The HERV-K115 insertion appeared to be more frequent in patients with younger onset than those with later onset. These results preliminarily suggest that HERV-K115 may not be associated with schizophrenia in general, but that it could play a partial role in early precipitation of the disease.
- Subjects :
- Adult
Male
Psychosis
viruses
Endogenous retrovirus
Disease
Pathogenesis
Retrovirus
Japan
Polymorphism (computer science)
medicine
Humans
In patient
Age of Onset
Polymorphism, Genetic
biology
General Neuroscience
Endogenous Retroviruses
Middle Aged
medicine.disease
biology.organism_classification
Virology
Mutagenesis, Insertional
Schizophrenia
embryonic structures
Immunology
DNA, Viral
Female
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 408
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....8c93499fedd7a40659e9113b7b5da5bf