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Comparison of capillary electrophoretic and liquid chromatographic determination of hypoxanthine and xanthine for the diagnosis of xanthinuria
- Source :
- Journal of Chromatography A. 730:329-331
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- A capillary electrophoretic (CE) method for the determination of hypoxanthine and xanthine in urine was developed to diagnose xanthinuria. The linearity was excellent up to 200 μmol l−1 for the two compounds and the limit of quantitation was 2 μmol 1−1. A comparison o the results obtained using CE was made with those obtained by the high-performance liquid chromatographic (HPLC) technique described previously. With regard to specificity, sensitivity and reproducibility, the results are similar but CE is more rapid than HPLC.
- Subjects :
- Detection limit
Hypoxanthine
Purine-Pyrimidine Metabolism, Inborn Errors
Reproducibility
Chromatography
Organic Chemistry
Electrophoresis, Capillary
General Medicine
Xanthine
medicine.disease
Biochemistry
High-performance liquid chromatography
Analytical Chemistry
chemistry.chemical_compound
Capillary electrophoresis
chemistry
Hypoxanthines
Xanthines
medicine
Humans
Xanthinuria
Quantitative analysis (chemistry)
Chromatography, High Pressure Liquid
Subjects
Details
- ISSN :
- 00219673
- Volume :
- 730
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....8c8a7905c23fdbb1c7e8cf4d6c4ff537