Back to Search
Start Over
Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats
- Source :
- Journal of ethnopharmacology. 90(1)
- Publication Year :
- 2003
-
Abstract
- The effect of Azadirachta indica extract on gastric ulceration was studied in albino rats. Azadirachta indica extract (100–800 mg/kg p.o., 100–250 mg/kg i.p.) significantly inhibited gastric ulceration induced by indomethacin (40 mg/kg). Administration of 800 mg/kg p.o. and 250 mg/kg i.p. caused 100% cytoprotection against indomethacin (40 mg/kg, i.p.)-induced gastric ulceration. This action was accompanied by a dose-dependent decrease in total gastric acidity. In order to investigate the probable mechanism of Azadirachta indica antiulcer activity, the effect of the extract alone and in combination with histamine (1 mg/kg) and cimetidine (0.12 mg/kg) on gastric acid secretion in situ was studied. Azadirachta indica (250 mg/kg) significantly inhibited the basal and histamine-induced gastric acid secretion. Cimetidine seemed to augment Azadirachta indica inhibition of gastric acid secretion. The results suggest that the stem bark extract of Azadirachta indica possesses antiulcer agents, which probably act via histamine H 2 receptor.
- Subjects :
- Male
Indomethacin
Pharmacognosy
Gastric Acid
chemistry.chemical_compound
parasitic diseases
Drug Discovery
medicine
Toxicity Tests, Acute
Animals
Stomach Ulcer
Cimetidine
Rats, Wistar
Pharmacology
Meliaceae
Azadirachta
biology
Traditional medicine
Plant Extracts
Stomach
food and beverages
biology.organism_classification
Anti-Ulcer Agents
Cytoprotection
digestive system diseases
Rats
medicine.anatomical_structure
chemistry
Plant Bark
Gastric acid
Drug Therapy, Combination
Histamine
medicine.drug
Phytotherapy
Subjects
Details
- ISSN :
- 03788741
- Volume :
- 90
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....8c7d8d87ae3d7fd25c54195a8b6c484d