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In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers
- Source :
- Contact lensanterior eye : the journal of the British Contact Lens Association. 41(6)
- Publication Year :
- 2018
-
Abstract
- Purpose To compare the in vitro anti-demodectic activity of four commercially available dedicated eyelid cleansers (Cliradex® towelette cleanser, Oust™ Demodex® cleanser, Blephadex™ eyelid foam, TheraTears® SteriLid® eyelid cleanser), tea tree oil, undiluted terpinen-4-ol and linalool; and to assess the terpinen-4-ol content of the commercial cleansers and tea tree oil. Methods In vitro anti-demodectic efficacy assessment: 93 viable Demodex mites were acquired from the epilated eyelashes of 10 participants, and were randomised to application with one of the four eyelid cleansers, 100% and 50% tea tree oil, undiluted terpinen-4-ol and linalool, or no treatment. Following treatment application, mite viability was assessed for 300 min, based on limb/body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed. Mass spectrometry analysis The absolute concentration of terpinen-4-ol and the relative abundance of linalool in the four eyelid cleansers and tea tree oil were determined. Results In vitro anti-demodectic efficacy assessment: No significant differences were observed between undiluted tea tree oil, terpinen-4-ol and linalool (all p > 0.05). Although all commercial eyelid cleansers effected lower mite survival probabilities than the untreated group, Cliradex® was the only eyelid cleanser that demonstrated comparable antiparastic activity to 50% tea tree oil (p = 0.36). Mass spectrometry analysis Among the four eyelid cleansers, Cliradex® contained the highest concentration of terpinen-4-ol, while linalool was present in TheraTears® SteriLid® only. Conclusions Of the four commercial eyelid cleansers, Cliradex® demonstrated the highest levels of in vitro anti-demodectic activity and terpinen-4-ol content. Undiluted linalool and terpenin-4-ol showed comparable antiparasitic efficacy, and the use of linalool in the management of demodectic blepharitis warrants further investigation.
- Subjects :
- Adult
Male
Administration, Topical
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Linalool
Cleanser
medicine
Animals
Humans
030212 general & internal medicine
Eye Infections, Parasitic
Blepharitis
Aged
Eyelashes
Mites
biology
Traditional medicine
business.industry
Terpenes
Terpinen-4-ol
Tea tree oil
Eyelids
Body movement
General Medicine
Middle Aged
biology.organism_classification
medicine.disease
Ophthalmology
medicine.anatomical_structure
Treatment Outcome
chemistry
030221 ophthalmology & optometry
Female
Eyelid
business
Demodex
Optometry
medicine.drug
Subjects
Details
- ISSN :
- 14765411
- Volume :
- 41
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Contact lensanterior eye : the journal of the British Contact Lens Association
- Accession number :
- edsair.doi.dedup.....8c6f39d122b6a378234a9e03e695a13e