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Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile
- Source :
- BMJ Open
- Publication Year :
- 2019
- Publisher :
- BMJ, 2019.
-
Abstract
- PurposeThe Chinese Longitudinal Healthy Longevity Survey Biomarkers Cohort (Healthy Ageing and Biomarkers Cohort Study (HABCS)) was established to investigate the determinants of healthy aging and mortality among the oldest old in China. Besides collecting health status, behavioural and sociodemographic circumstances, the present study also gathers comprehensive data for the elderly by simultaneously collecting, detecting, analysing blood and urine, respectively.ParticipantsHABCS is a community-based longitudinal multiwave study of older men and women aged 65 or above. Baseline survey and the follow-up surveys with replacement for deceased elderly were conducted in eight longevity areas in China, which cover the northern, middle and southern parts of China. Between 2008 and 2017, 6333 participants were included in HABCS, comprising 1385 centenarians, 1350 nonagenarians, 1294 octogenarians, 1577 younger elderly (aged 65–79).Findings to dateWe have found that higher baseline levels of (1) total cholesterol, (2) low-density lipoprotein cholesterol (LDL-C) and (3) superoxide dismutase activity were associated with greater cognitive decline. While (4) higher LDL-C level was associated with lower risk of all-cause mortality. There was a reverse association between (5) plasma vitamin D and cognitive impairment in cross-sectional and prospective study.Future plansWe are currently exploring the relationships between various biomarkers and different outcomes such as cognitive function and mortality. This longitudinal cohort study will be continued in the future.
- Subjects :
- Male
Gerontology
China
Chinese oldest old
Epidemiology
media_common.quotation_subject
Lower risk
Cohort Studies
Healthy Aging
03 medical and health sciences
0302 clinical medicine
Vitamin D and neurology
Humans
Medicine
Longitudinal Studies
Prospective Studies
030212 general & internal medicine
Cognitive decline
Prospective cohort study
Aged
The Healthy Aging and Biomarkers Cohort Study
media_common
Aged, 80 and over
Cohort Profile
business.industry
Longevity
Cognition
General Medicine
3. Good health
Cross-Sectional Studies
HABCS
Cohort
Female
business
Biomarkers
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 20446055
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- BMJ Open
- Accession number :
- edsair.doi.dedup.....8c678ea663ea0bea04816d20c2094212