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MR-guided laser ablation for the treatment of hypothalamic hamartomas
- Source :
- Epilepsy research. 142
- Publication Year :
- 2017
-
Abstract
- Hypothalamic hamartoma is an archetypal example of subcortical epilepsy that can be associated with intractable gelastic epilepsy, secondary epilepsy, and epileptic encephalopathy. The history of its surgical treatment is fraught with mislocalization of the seizure focus, modest efficacy and a high complication rate. Many minimally invasive techniques have been described to mitigate this high complication profile of which MR-guided laser ablation is one. The technology combines instant effect of thermal coagulation with stereotactic precision and guidance with real time MR thermography. This article presents a series of 71 hypothalamic hamartoma patients operated with laser ablation. Ninety-three percent (93%) were free of gelastic seizures at one year with 23% of the patients requiring more than one ablation. One patient experienced a significant memory deficit and one patient experienced worsening diabetes insipidus. Stereotactic laser ablation appears to be a safe and effective surgical option in the treatment of hypothalamic hamartoma.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Hamartoma
Cohort Studies
03 medical and health sciences
Epilepsy
Young Adult
0302 clinical medicine
Imaging, Three-Dimensional
Hypothalamic hamartoma
Gelastic seizure
Electrocoagulation
Medicine
Humans
Child
Laser ablation
business.industry
Infant
medicine.disease
Ablation
Magnetic Resonance Imaging
Treatment Outcome
Neurology
030220 oncology & carcinogenesis
Child, Preschool
Diabetes insipidus
Female
Neurology (clinical)
Radiology
Laser Therapy
medicine.symptom
business
Complication
030217 neurology & neurosurgery
Mri guided
Hypothalamic Diseases
Subjects
Details
- ISSN :
- 18726844
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Epilepsy research
- Accession number :
- edsair.doi.dedup.....8c57ea0456de88a0e531b688aa8ed183