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Macrophage and osteoblast responses to biphasic calcium phosphate microparticles
- Source :
- Journal of Biomedical Materials Research Part A, Journal of Biomedical Materials Research Part A, Wiley, 2009, pp.n/a-n/a. ⟨10.1002/jbm.a.32663⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- The aim of this work was to investigate in vitro the biological events leading to ectopic bone formation in contact with microporous biphasic calcium phosphate (BCP) ceramics. After implantation, microparticles may arise from their degradation and induce an inflammatory response involving macrophages. The secretion of pro-inflammatory cytokines may affect the differentiation of osteoblasts. Mouse macrophage-like (J774) and osteoblast-like (MC3T3-E1) cells were cultured in the presence of BCP microparticles of different sizes (
- Subjects :
- Calcium Phosphates
medicine.medical_specialty
Materials science
medicine.medical_treatment
Osteocalcin
Biomedical Engineering
Core Binding Factor Alpha 1 Subunit
Enzyme-Linked Immunosorbent Assay
Inflammation
02 engineering and technology
3T3 cells
Biomaterials
Mice
03 medical and health sciences
Internal medicine
medicine
Animals
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
Osteoblasts
biology
Reverse Transcriptase Polymerase Chain Reaction
Macrophages
Metals and Alloys
Osteoblast
3T3 Cells
Alkaline Phosphatase
021001 nanoscience & nanotechnology
Molecular biology
Microspheres
In vitro
RUNX2
Cytokine
medicine.anatomical_structure
Endocrinology
Sp7 Transcription Factor
Ceramics and Composites
biology.protein
Cytokines
Alkaline phosphatase
medicine.symptom
0210 nano-technology
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 15493296 and 15524965
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Materials Research Part A, Journal of Biomedical Materials Research Part A, Wiley, 2009, pp.n/a-n/a. ⟨10.1002/jbm.a.32663⟩
- Accession number :
- edsair.doi.dedup.....8c55e5888c2b735eb7f0dde021b637ae