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Structure-Switchable DNA Programmed Disassembly of Nanoparticles for Smart Size Tunability and Cancer-Specific Drug Release
- Source :
- ACS Applied Materials & Interfaces. 12:22560-22571
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- The size of the nanocarrier is considered one of the most important issues for its therapeutic effect. Thus, an intelligent nanocarrier with dynamic size has been explored as a promising approach to fulfill the requirements for both efficient accumulation according to the enhanced penetration and retention (EPR) effect and deep penetration into tumor tissue. Herein, structure-switchable triplex DNA was modified on gold nanoparticles (AuNPs) to investigate its potential to modulate the nanoparticle dynamic disassembly process among the tumor microenvironment. We report that the pH-sensitive triplex DNA exhibited outstanding sensitivity and size tunability in triggering the disassembly of AuNP clusters into smaller sizes among the tumor acidic environment, leading to better permeability both in vitro and in vivo. By further combination of the telomerase-sensitive hairpin DNA loaded with chemotherapy drug doxorubicin (DOX), a cancer-specific intracellular drug-release function was also realized, resulting in a precise treatment effect and lower toxicity on normal cells. Through comodification of these two structure-switchable DNA chains on AuNPs and construction of nanoparticle assemblies with proper size, programmed disassembly and drug-release function in tissue and cell level, respectively, were successfully combined and eventually facilitated a highly efficient nanodrug transportation process, from tumor accumulation to deep penetration and precise cancer chemotherapy. The study provided the prospect of utilizing functionalized DNA in optimization of nanocarrier delivery efficiency.
- Subjects :
- Materials science
Metal Nanoparticles
Nanoparticle
Antineoplastic Agents
02 engineering and technology
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
In vivo
Cell Line, Tumor
Neoplasms
medicine
Animals
Humans
General Materials Science
Doxorubicin
Telomerase
Drug Carriers
Mice, Inbred BALB C
Tumor microenvironment
Inverted Repeat Sequences
DNA
Penetration (firestop)
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
Drug Liberation
chemistry
Colloidal gold
Biophysics
Nucleic Acid Conformation
Female
Gold
Drug Screening Assays, Antitumor
Nanocarriers
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....8c53b980c7490065fed172281291b115