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Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

Authors :
Ivana Ostadalova
V Olejnickova
O Szarszoi
Marketa Hlavackova
I Netuka
Bohuslav Ostadal
Source :
Canadian Journal of Physiology and Pharmacology. 99:1-8
Publication Year :
2021
Publisher :
Canadian Science Publishing, 2021.

Abstract

Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.

Details

ISSN :
12057541 and 00084212
Volume :
99
Database :
OpenAIRE
Journal :
Canadian Journal of Physiology and Pharmacology
Accession number :
edsair.doi.dedup.....8c489b0558f1083a91a78a77a90f6c7d
Full Text :
https://doi.org/10.1139/cjpp-2020-0310