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Operon structure and cotranslational subunit association direct protein assembly in bacteria
- Source :
- Science. 350:678-680
- Publication Year :
- 2015
- Publisher :
- American Association for the Advancement of Science (AAAS), 2015.
-
Abstract
- Proximity best for building protein complexes The synthesis of protein subunits and their assembly into a fully functional complex are generally thought to be two distinct processes. Shieh et al. studied the synthesis and assembly of the luciferase complex in Escherichia coli. Organization of the luciferase subunits LuxA and LuxB side by side into an operon promotes their colocalized synthesis and assembly into an active enzyme complex. Indeed, the association between the subunits occurs as they are being synthesized on ribosomes, which helps order the sequence of subunit interactions. Science , this issue p. 678
- Subjects :
- Operon
Recombinant Fusion Proteins
Protein subunit
Green Fluorescent Proteins
Ribosome
Protein Structure, Secondary
Protein structure
Bacterial Proteins
Gene Order
Escherichia coli
Protein biosynthesis
RNA, Messenger
Vibrio
Genetics
Multidisciplinary
Bacteria
biology
RNA
Cell biology
Luciferases, Bacterial
Luminescent Proteins
Protein Subunits
Cytosol
Genes, Bacterial
Protein Biosynthesis
Chaperone (protein)
biology.protein
Ribosomes
Molecular Chaperones
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 350
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....8c44e7b292f8ea0c097eda8a14acb09b