Back to Search
Start Over
Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles
- Source :
- Environmental Toxicology and Pharmacology. 33:16-25
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- This study investigated the accumulation of cadmium (0-8 mg Cd L-1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at >= 4 mg L-1 Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue. (C) 2011 Published by Elsevier B.V.
- Subjects :
- Gills
medicine.medical_specialty
Antioxidant
Health, Toxicology and Mutagenesis
medicine.medical_treatment
chemistry.chemical_element
Flounder
Biology
Kidney
Toxicology
medicine.disease_cause
Antioxidants
Lipid peroxidation
chemistry.chemical_compound
Internal medicine
medicine
Animals
Humans
Tissue Distribution
Muscle, Skeletal
Glutathione Transferase
Pharmacology
Glutathione Peroxidase
Cadmium
Kidney metabolism
General Medicine
Glutathione
biology.organism_classification
Olive flounder
Oxidative Stress
medicine.anatomical_structure
Endocrinology
Liver
chemistry
Lipid Peroxidation
Biomarkers
Water Pollutants, Chemical
Oxidative stress
Subjects
Details
- ISSN :
- 13826689
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Environmental Toxicology and Pharmacology
- Accession number :
- edsair.doi.dedup.....8c3e29a6a04eedfbc322a0cd2d7765b6