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Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1
- Source :
- eNeuro
- Publication Year :
- 2019
- Publisher :
- Society for Neuroscience, 2019.
-
Abstract
- A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). While the difference between cell classes is clear when the stimulus strength is high, reducing stimulus strength diminishes the differences between the cell types and causes some complex cells to respond as simple cells (Crowder et al., 2007; van Kleef et al., 2010; Hietanen et al., 2013). To understand the synaptic basis for this shift in behavior, we usedin vivowhole-cell recordings while systematically shifting stimulus contrast. We find systematic shifts in the degree of complex cell responses in mouse primary visual cortex (V1) at the subthreshold level, demonstrating that synaptic inputs change in concert with the shifts in response linearity and that the change in response linearity is not simply due to the threshold nonlinearity. These shifts are consistent with a visual cortex model in which the recurrent amplification acts as a critical component in the generation of complex cell responses (Chance et al., 1999).
- Subjects :
- phase sensitivity
Male
Cell type
Patch-Clamp Techniques
in vivo whole-cell recording
Stimulus (physiology)
Membrane Potentials
Contrast Sensitivity
Mice
medicine
Animals
Patch clamp
primary visual cortex
Visual Cortex
Membrane potential
Neurons
Subthreshold conduction
Chemistry
General Neuroscience
Linearity
General Medicine
Complex cell
New Research
complex cell
Mice, Inbred C57BL
Visual cortex
medicine.anatomical_structure
Pattern Recognition, Visual
8.1
Sensory and Motor Systems
visual system
Female
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 23732822
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- eNeuro
- Accession number :
- edsair.doi.dedup.....8c3d11909169371436bff09924c58284