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One new flavanocoumarin from the thorns of Gleditsia sinensis
- Source :
- Natural product research. 31(3)
- Publication Year :
- 2016
-
Abstract
- One new flavanocoumarin (1), as well as six known flavonoids (2–7), was isolated from the ethyl acetate extract of the thorns of Gleditsia sinensis. The structures of these compounds were elucidated by extensive spectroscopic measurements and comparison with data reported in literatures. Cytotoxic activities of compounds 1–6 were evaluated against human liver cancer SK-hep-1 cells in vitro by the MTT method, with compound 1 displaying moderate activity (IC50 of 62.53 μM). Furthermore, compound 1 could increase the number of apoptosis cells in a concentration-dependent manner.
- Subjects :
- Ethyl acetate
Moderate activity
Antineoplastic Agents
Apoptosis
Plant Science
01 natural sciences
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Coumarins
Cell Line, Tumor
Gleditsia
Cytotoxic T cell
Humans
IC50
Flavonoids
biology
Traditional medicine
Molecular Structure
010405 organic chemistry
Plant Extracts
Spectrum Analysis
Organic Chemistry
Liver Neoplasms
Mtt method
biology.organism_classification
In vitro
0104 chemical sciences
Gleditsia sinensis
010404 medicinal & biomolecular chemistry
chemistry
Subjects
Details
- ISSN :
- 14786427
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....8c3c9c745b3db607a2efbf848189b60f