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Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy
- Source :
- The Journal of Veterinary Medical Science
- Publication Year :
- 2017
- Publisher :
- Japanese Society of Veterinary Science, 2017.
-
Abstract
- It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE.
- Subjects :
- Male
0301 basic medicine
Thymic stromal lymphopoietin
Colon
Duodenum
040301 veterinary sciences
Inflammatory bowel disease
0403 veterinary science
Pathogenesis
03 medical and health sciences
Dogs
Thymic Stromal Lymphopoietin
inflammatory bowel disease
Immunity
Internal Medicine
food-responsive enteropathy
medicine
Animals
Enteropathy
Dog Diseases
RNA, Messenger
Intestinal Mucosa
General Veterinary
business.industry
Interleukin-17
Interleukin
04 agricultural and veterinary sciences
Interleukin-33
Note
medicine.disease
Epithelium
chronic enteropathy
Intestinal Diseases
030104 developmental biology
medicine.anatomical_structure
epithelial cell-derived cytokines
Chronic Disease
Immunology
Cytokines
dog cytokines
business
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....8c30ba731521d2ff60e71dcad04d4e2e