Back to Search
Start Over
Bone Healing of Tibial Lengthening Is Delayed by Cigarette Smoking
- Source :
- The Journal of Trauma: Injury, Infection, and Critical Care. 46:110-115
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- Objective: We investigated the effect of intermittent cigarette smoke inhalation on the bone healing of tibial lengthening in rabbits. Methods: Twelve male rabbits were divided into two groups of six animals each. The first group underwent intermittent cigarette smoke inhalation, and the second group did not undergo intermittent cigarette smoke inhalation. Each animal's right tibia was lengthened 5 mm by using an uniplanar lengthening device. Bone mineral density (BMD) study was performed for all of the animals 1 day before operation and 3, 4, 5, and 6 weeks after operation. All of the animals were killed 6 weeks postoperatively for biomechanical testing. Results: By using the preoperative BMD as an internal control, we found that the BMD of the smoke-inhalation group was decreased significantly compared with the non-smoke-inhalation group. The mean %BMD at 3, 4, 5, and 6 weeks were 49.9%, 61.2%, 65.9%, and 71.0%, respectively, in the smoke-inhalation group, whereas the mean %BMD were 54.9%, 71.8%, 76.4%, and 82.0%, respectively, in the non-smoke-inhalation group (two-tailed t test, p > 0.05, p < 0.01, p < 0.01 and p < 0.01 at 3, 4, 5, and 6 weeks, respectively). By using the contralateral nonoperated tibia as internal control, we found that torsional strength of the smoke-inhalation group was decreased significantly compared with the non-smoke-inhalation group. The mean percentage of maximal torque was 63.8% in the smoke-inhalation group, whereas the mean percentage of maximal torque was 77.1% in the non-smoke-inhalation group (two tailed t test, p < 0.01). Conclusion: This study suggests that cigarette smoking delays the mineralization during the bone healing process of distraction osteogenesis and, thus, decreases the mechanical strength of the regenerating bone.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Bone healing
Random Allocation
Absorptiometry, Photon
Calcification, Physiologic
Cigarette smoking
Bone Density
Bone Lengthening
medicine
Animals
Tibia
Bone mineral
Inhalation
business.industry
Torsional strength
Smoking
Biomechanics
Biomechanical Phenomena
Surgery
Anesthesia
Distraction osteogenesis
Rabbits
Stress, Mechanical
business
Subjects
Details
- ISSN :
- 10796061
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- The Journal of Trauma: Injury, Infection, and Critical Care
- Accession number :
- edsair.doi.dedup.....8c2fa6fe639193cbec283d197b5a105c
- Full Text :
- https://doi.org/10.1097/00005373-199901000-00018