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Accurate Risk Stratification of Patients with Node-Positive Gastric Cancer by Lymph Node Ratio
- Source :
- World Journal of Surgery. 44:4184-4192
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- We aimed to clarify the utility of lymph node ratio (LNR) for assessing the prognosis of patients with node-positive gastric cancer after curative gastrectomy. We retrospectively analyzed data of 973 patients with node-positive gastric cancer who had undergone curative gastrectomy at nine institutions from 2010 to 2014. Survival analysis was performed by comparing LNR low and high groups according to the optimal cutoff value of LNR, which was determined using receiver operating characteristic curve analysis. LNR high was significantly associated with shorter disease-free survival and was an independent predictor of recurrence in all patients. Moreover, we obtained the similar results from analysis of each N stage. The prevalence of lymph node and peritoneal recurrence appeared to be higher in the LNR high group. Correlation analysis showed that LNR was negatively correlated with the number of retrieved nodes within every N stage; however, disease-free survival did not differ significantly between LNR low and high groups of each N stage with 16–30, 31–40, or >40 retrieved nodes. LNR is a strong prognostic factor and predictor of recurrence in patients with node-positive gastric cancer who have undergone curative gastrectomy. The combination of LNR and N staging permits more accurate prognostic stratification of patients with gastric cancer and may contribute to developing novel prognostic models.
- Subjects :
- medicine.medical_specialty
Risk Assessment
Gastroenterology
Stomach Neoplasms
Internal medicine
medicine
Humans
High group
Lymph node
Survival analysis
Neoplasm Staging
Retrospective Studies
Receiver operating characteristic
business.industry
Cancer
Prognosis
medicine.disease
medicine.anatomical_structure
Cardiothoracic surgery
Lymphatic Metastasis
Risk stratification
Lymph Node Excision
Surgery
Lymph Nodes
Neoplasm Recurrence, Local
business
Lymph Node Ratio
Abdominal surgery
Subjects
Details
- ISSN :
- 14322323 and 03642313
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgery
- Accession number :
- edsair.doi.dedup.....8c25e0e2d369cee07060b93eaf00fdda