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Protective effect of naturally occurring anti-HER2 autoantibodies on breast cancer
- Source :
- Breast Cancer Research and Treatment. 157:55-63
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Anti-HER2-autoantibodies (HER2-AAbs) are found in breast cancer patients as well as healthy individuals. However, the clinical relevance of the antibodies is unknown. We established an enzyme-linked immunosorbent assay with high sensitivity and quantified serum HER2-AAbs in 100 healthy women, 100 untreated patients with ductal carcinoma in situ (DCIS), and 500 untreated patients with invasive breast carcinoma (IBC). The associations between the levels of HER2-AAbs and breast cancer risk, and recurrence-free survival, were examined. High levels of HER2-AAbs were significantly associated with a reduced risk of DCIS (odds ratio [OR] 0.19, P = 4.6 × 10(-7)) or IBC (OR 0.31, P = 3.7 × 10(-7)). Subgroup analysis of IBC revealed a stronger association of HER2-AAbs with a reduced risk of the hormone receptor (HR)(-)/HER2(+) subtype (OR 0.12) than the other subtypes (HR(+)/HER2(-) [OR = 0.32], HR(+)/HER2(+) [OR 0.38], and HR(-)/HER2(-) [OR 0.29]). When we set the cutoff of HER2-AAbs at 20 ng/mL, recurrence-free survival of HER2-AAb-positive patients (N = 74) was significantly better than that of HER2-AAb-negative patients (N = 426) (P = 0.015). Univariate and multivariate analyses demonstrated that HER2-AAbs, as well as histological grade, were independently and significantly (P = 0.0065 and 0.049, respectively) associated with recurrence-free survival. Our exploratory study suggests a protective effect of naturally occurring HER2-AAbs on the development of primary and recurrent breast cancer. Further studies on HER2-AAbs are warranted.
- Subjects :
- Adult
0301 basic medicine
Cancer Research
medicine.medical_specialty
Receptor, ErbB-2
Breast Neoplasms
Subgroup analysis
Gastroenterology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Odds Ratio
medicine
Humans
Clinical significance
skin and connective tissue diseases
neoplasms
Aged
Autoantibodies
Aged, 80 and over
biology
business.industry
Carcinoma, Ductal, Breast
Autoantibody
Odds ratio
Middle Aged
Ductal carcinoma
medicine.disease
030104 developmental biology
Endocrinology
Oncology
Hormone receptor
030220 oncology & carcinogenesis
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....8c228c3c7931285c766018e4aeacddc2