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Effect of hypertonic saline on vascular responses to angiotensin II in pregnancy
- Source :
- American Journal of Obstetrics and Gynecology. 147:231-240
- Publication Year :
- 1983
- Publisher :
- Elsevier BV, 1983.
-
Abstract
- Refractoriness to infused angiotensin II is characteristic or normal human and ovine pregnancy; the mechanisms responsible are unclear. In this study, we sought to ascertain in gravid sheep whether hypertonic saline solution alters the vascular responses to angiotensin II, as in gravid women, and to compare the responses of the systemic and uteroplacental vasculature. Dose-response curves were determined. Mean arterial pressure and systemic vascular resistance increased in a dose-dependent fashion before and after hypertonic saline solution; responses were greater after hypertonic saline solution (p less than 0.01). Responses of cardiac output, heart rate, uterine vascular resistance, and uterine blood flow also were dose-dependent, but were unchanged after hypertonic saline solution. Plasma renin activity fell 45% after hypertonic saline solution. Treatment with hypertonic saline solution results in increased pressor responses to angiotensin II that are not a reflection of altered baroreceptor or chemoreceptor reflexes or of the response in the uteroplacental vascular bed. Rather, the increased systemic vascular responsiveness to angiotensin II after hypertonic saline solution appears to be a reflection of other mechanisms, such as alterations in vessel wall dynamics or receptor affinity.
- Subjects :
- medicine.medical_specialty
Mean arterial pressure
Hemodynamics
Sodium Chloride
Peptide hormone
Heart Rate
Pregnancy
Internal medicine
medicine
Animals
Cardiac Output
Saline Solution, Hypertonic
Sheep
Dose-Response Relationship, Drug
business.industry
Angiotensin II
Uterus
Obstetrics and Gynecology
Hypertonic saline
medicine.anatomical_structure
Endocrinology
Regional Blood Flow
Vascular resistance
Pregnancy, Animal
Gestation
Tonicity
Female
Vascular Resistance
business
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....8c20c2775a6e4f572b5d53c62657950a