Quantitative perfusion histogram parameters of dynamic contrast-enhanced MRI to identify different pathological types of uterine leiomyoma

OBJECTIVE: :To explore the value of quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） in pathological classification of uterine leiomyoma and its correlation with Ki-67 protein expression. METHODS: Thirty five patients with uterine leiomyoma confirmed by operation and pathology at Shaoxing People’s Hospital from October 2015 to September 2017 were analyzed retrospectively，including 15 cases of ordinary type，8 cases of cellular type and 12 cases of degenerative type. All patients were examined by pelvic DCE-MRI before operation，and the histogram parameters （median，mean，skewness，kurtosis，energy，entropy） of various quantitative perfusion parameters，including volume transport constant （K (trans)），rate constant （K (ep)），extravascular extracellular space distribute volume per unit tissue volume （V (e)），blood plasma volume per unit volume of tissue （V (p)） were calculated，and the efficacy of different parameters in pathological classification of uterine leiomyoma was evaluated by ROC curve. The expression of Ki-67 protein in uterine leiomyoma was detected by immunohistochemical method，and the correlation between histogram parameters and Ki-67 protein expression was analyzed by Pearson and Spearman correlation analysis. RESULTS: The median and mean values of K (trans)，K (ep)，V (e) and V (p) in the cellular group were higher than those in the degenerative group and the ordinary group（ P