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The Prognostic Significance of Tryptophanyl-tRNA Synthetase in Colorectal Cancer
- Source :
- Cancer Epidemiology, Biomarkers & Prevention. 18:2949-2956
- Publication Year :
- 2009
- Publisher :
- American Association for Cancer Research (AACR), 2009.
-
Abstract
- Background: Tryptophanyl-tRNA synthetase (TrpRS) is an aminoacyl-tRNA synthetase involved in protein synthesis and regulation of RNA transcription and translation and is an inhibitor of angiogenesis. TrpRS has been shown to be differentially expressed in colorectal cancer (CRC) and has thus been identified as a potential prognostic marker. The aim of this study was to analyze the correlation of TrpRS to the prognosis of patients diagnosed and treated for CRC within a defined population. Methods: With a polyclonal, monospecific IgG antibody, TrpRS expression was assessed by immunohistochemistry on tissue microarrays with tumors from a population-based CRC cohort (n = 320). Staining intensity and fraction of positive tumor cells were recorded. A Cox multivariate model including TrpRS expression, carcinoembryonic antigen, age, stage, tumor differentiation, and lymphatic and vascular vessel invasion was used to calculate the hazard ratio and 95% confidence interval (95% CI) for time to recurrence, disease-free survival, and overall survival. Results: Low expression of TrpRS correlated to increased risk for lymph node metastasis (P = 0.025) and a more advanced tumor stage (P = 0.001). Patients with tumors and increased levels of TrpRS expression had better survival than patients with low expression levels. Multivariate analyses revealed significantly better disease-free survival (relative risk, 0.59; 95% CI, 0.38-0.95) for patients with high expression than for patients with low expression of TrpRS. For colon cancer patients, a reduced risk for recurrence was seen in patients with increased TrpRS expression (relative risk, 0.23; 95% CI, 0.07-0.80). Conclusion: Low expression of TrpRS in tumor tissue correlates with increased risk for recurrence and worse survival in patients with CRC. This can be related to its antiangiogenic properties and could aid in the future selection of new drugs in the treatment of CRC. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2949–56)
- Subjects :
- Oncology
medicine.medical_specialty
Pathology
Epidemiology
Colorectal cancer
Population
Tryptophan-tRNA Ligase
Metastasis
Cohort Studies
Immunoenzyme Techniques
Carcinoembryonic antigen
Internal medicine
medicine
Humans
Neoplasm Invasiveness
education
Neoplasm Staging
education.field_of_study
Mucous Membrane
Tissue microarray
biology
business.industry
Hazard ratio
Cancer
Cell Differentiation
Prognosis
medicine.disease
Carcinoembryonic Antigen
Survival Rate
Tissue Array Analysis
Lymphatic Metastasis
biology.protein
Immunohistochemistry
Lymph Nodes
Neoplasm Recurrence, Local
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....8bfe1514363ad7750ee6ba7ccd34cf2e