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Antiangiogenic agents as a maintenance strategy for advanced epithelial ovarian cancer
- Source :
- Critical Reviews in Oncology/Hematology. 86:161-175
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Bevacizumab is the first antiangiogenic agent to have demonstrated benefit as first-line and maintenance therapy in epithelial ovarian cancer (EOC), with the Gynecologic Oncology Group 218 and ICON 7 phase III trials revealing significantly prolonged progression-free survival (PFS) for carboplatin/paclitaxel plus bevacizumab followed by bevacizumab maintenance versus carboplatin/paclitaxel alone. Results are forthcoming from several phase III maintenance trials of investigational antiangiogenic agents, each evaluating PFS as the primary endpoint: AGO-OVAR12/LUME-Ovar1 (nintedanib [BIBF 1120]), AGO-OVAR16 (pazopanib), and TRINOVA-1, -2, and -3 (AMG 386). Here we review available data and ongoing clinical trials of investigational antiangiogenic agents as maintenance therapy for EOC. Current controversies, including uncertainties regarding the (1) most appropriate clinical trial endpoints, (2) optimal dosing, duration, and timing of therapy (e.g., with first-line chemotherapy and/or as maintenance monotherapy), and (3) feasibility, tolerability, and cost of adding these agents to platinum/taxane regimens are also highlighted.
- Subjects :
- Vascular Endothelial Growth Factor A
Oncology
medicine.medical_specialty
Bevacizumab
Angiogenesis Inhibitors
Carcinoma, Ovarian Epithelial
Pharmacology
Antibodies, Monoclonal, Humanized
Pazopanib
chemistry.chemical_compound
Maintenance therapy
Internal medicine
medicine
Clinical endpoint
Animals
Humans
Molecular Targeted Therapy
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Clinical Trials as Topic
Taxane
business.industry
Ovary
Hematology
Carboplatin
Clinical trial
chemistry
Female
Nintedanib
business
medicine.drug
Subjects
Details
- ISSN :
- 10408428
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Oncology/Hematology
- Accession number :
- edsair.doi.dedup.....8bfd7607902cba1f9008cdc956ecf275