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Effect of pyridoxine supplementation on plasma oxalate concentrations in patients receiving dialysis
- Source :
- European Journal of Clinical Investigation. 19:201-205
- Publication Year :
- 1989
- Publisher :
- Wiley, 1989.
-
Abstract
- Plasma oxalate and erythrocyte glutamic oxaloacetate transaminase activity (EGOT) (an indicator of nutritional status with respect to pyridoxine) were measured in 21 patients maintained on regular continuous ambulatory peritoneal dialysis or haemodialysis before and after a 4-month period of supplementation with pyridoxine, 100 mg day-1. Prior to supplementation 10/21 patients showed subnormal EGOT activity, although the increment in activity on addition of pyridoxal-5-phosphate in vitro was within the normal range in all cases. Mean plasma oxalate was 31.5 μmol 1-1 (SEM 2.9) prior to supplementation and did not change significantly with supplementation, despite normalization of EGOT activity in all but 2/21 patients. We conclude that pyridoxine deficiency does not contribute significantly to hyperoxalaemia in patients receiving dialysis and that 100 mg of pyridoxine daily is insufficient to reduce oxalate generation by a pharmacological action on glycine transamination.
- Subjects :
- medicine.medical_specialty
Erythrocytes
medicine.medical_treatment
Clinical Biochemistry
Biochemistry
Oxalate
Transaminase
chemistry.chemical_compound
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis
Internal medicine
medicine
Humans
Citrate synthase
Pyridoxine Deficiency
Aspartate Aminotransferases
Dialysis
Oxalates
biology
Chemistry
Oxalic Acid
Continuous ambulatory peritoneal dialysis
Pyridoxine
General Medicine
Endocrinology
Glycine
biology.protein
Kidney Failure, Chronic
Vitamin B 6 Deficiency
medicine.drug
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....8be36bc371e48e2a40f4283f8a410134