Back to Search
Start Over
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
- Source :
- Bioorganicmedicinal chemistry letters. 20(5)
- Publication Year :
- 2009
-
Abstract
- A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure–activity relationship data are also provided.
- Subjects :
- Benzoxazoles
Stereochemistry
Aryl
Organic Chemistry
Clinical Biochemistry
food and beverages
Pharmaceutical Science
Administration, Oral
Benzoxazole
Janus Kinase 2
Biochemistry
Rats
chemistry.chemical_compound
Structure-Activity Relationship
chemistry
Drug Discovery
Molecular Medicine
Animals
Janus kinase
Molecular Biology
Protein Kinase Inhibitors
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....8bddf41be25aecaef0f06f28d246bf79