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Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial
- Source :
- Brazilian Journal of Cardiovascular Surgery, Volume: 34, Issue: 5, Pages: 588-595, Published: 11 NOV 2019, Brazilian Journal of Cardiovascular Surgery v.34 n.5 2019, Brazilian Journal of Cardiovascular Surgery, Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV), instacron:SBCCV, Brazilian Journal of Cardiovascular Surgery, Vol 34, Iss 5, Pp 588-595 (2019)
- Publication Year :
- 2019
- Publisher :
- Sociedade Brasileira de Cirurgia Cardiovascular, 2019.
-
Abstract
- Objective: To evaluate the efficacy of triclosan-coated suture for the reduction of infection in saphenectomy wounds of patients undergoing coronary artery bypass graft (CABG) surgery. Methods: A total of 508 patients who underwent saphenectomy in CABG surgery were included in a prospective, randomized, double-blind trial from February/2011 to June/2014. Patients were randomized into the triclosan-coated suture group (n= 251) and the conventional non-antibiotic suture group (n=257). Demographic (gender and age), clinical (body mass index, diabetes, and use of analgesics), and intraoperative (cardiopulmonary bypass and cross-clamp times) variables and those related to the saphenectomy wound (pain, dehiscence, erythema, infection, necrosis, and hyperthermia) were measured and analyzed. Results: Of the 508 patients who underwent saphenectomy, 69.9% were males and 40.2% were diabetic. Thirty-three (6.5%) patients presented infection: 13 (5.3%) with triclosan and 20 (7.9%) with conventional suture (P=0.281). Among diabetic patients (n=204), triclosan suture was used in 45.1% with four cases of infection; conventional suture was used in 54.9% of them, with 11 cases of infection. Most patients (94.3%) underwent on-pump CABG. Wound pain was observed in 9.9% of patients with triclosan-coated suture and in 17.9% with conventional suture (P=0.011). Wound hyperthermia was found in 1.6% of patients with triclosan-coated suture and in 5.4% of those with conventional suture (P=0.028). Conclusion: Triclosan-coated suture shows lower infection rate in saphenectomy of patients undergoing CABG, although the differences were not statistically significant. Pain and wound hyperthermia were less frequent in patients with triclosan-coated sutures compared with conventional sutures.
- Subjects :
- Male
Time Factors
Erythema
030204 cardiovascular system & hematology
law.invention
Body Mass Index
0302 clinical medicine
Suture (anatomy)
Randomized controlled trial
law
Prospective Studies
Coronary Artery Bypass
Polyglactin 910
Aged, 80 and over
Pain, Postoperative
Analgesics
Cardiopulmonary Bypass
General Medicine
Middle Aged
medicine.anatomical_structure
Treatment Outcome
Female
Original Article
Coronary Artery Bypass Graft
medicine.symptom
Cardiology and Cardiovascular Medicine
Artery
Adult
medicine.medical_specialty
RD1-811
Pain
Dehiscence
Statistics, Nonparametric
Diabetes Complications
03 medical and health sciences
Double-Blind Method
Diabetes mellitus
medicine
Cardiopulmonary bypass
Humans
Surgical Wound Infection
Diseases of the circulatory (Cardiovascular) system
Saphenous Vein
Aged
Sutures
business.industry
Suture Techniques
Reproducibility of Results
medicine.disease
Triclosan
Surgery
RC666-701
Anti-Infective Agents, Local
Wound Infection
business
Body mass index
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Cardiovascular Surgery, Volume: 34, Issue: 5, Pages: 588-595, Published: 11 NOV 2019, Brazilian Journal of Cardiovascular Surgery v.34 n.5 2019, Brazilian Journal of Cardiovascular Surgery, Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV), instacron:SBCCV, Brazilian Journal of Cardiovascular Surgery, Vol 34, Iss 5, Pp 588-595 (2019)
- Accession number :
- edsair.doi.dedup.....8bdd1d9a03e8996e104abda15c26e1b6