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Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 19:1392-1395
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- A variety of new prodrugs of 2'-methyl cytidine based on acyloxy ethylamino phosphoramidates have been synthesized and tested in vitro and in vivo for their biological activity. Compared with the parent drug a 10- to 20-fold increase in formation of nucleotide triphosphate in rat and human hepatocytes could be achieved.
- Subjects :
- Hepatitis C virus
Clinical Biochemistry
Drug Evaluation, Preclinical
Pharmaceutical Science
Cytidine
Hepacivirus
Viral Nonstructural Proteins
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Dogs
In vivo
Drug Discovery
medicine
Animals
Humans
Phosphoric Acids
Prodrugs
Nucleotide
Molecular Biology
Cells, Cultured
chemistry.chemical_classification
Organic Chemistry
Biological activity
Phosphoramidate
Prodrug
RNA-Dependent RNA Polymerase
Amides
In vitro
Rats
chemistry
Hepatocytes
Molecular Medicine
Rabbits
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....8bd9d8136571293bd1dc41a8ee79d59f