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Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients
- Source :
- American Journal of Industrial Medicine
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Background Asbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma. Methods Seventy‐five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical‐legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers. Results All subjects had pathologically confirmed malignant mesothelioma. The mean age at diagnosis was 61 ± 17 years. The mean latency from exposure to diagnosis was 50 ± 13 years. The mean exposure duration was 33 ± 16 years. Four mesotheliomas (5%) occurred in individuals working as barbers/cosmetologists, or in a family member who swept the barber shop. Twelve (16%) occurred in individuals less than 45 years old (10 females; 2 males). Forty‐eight mesotheliomas were pleural (40 females; 8 males), 23 were peritoneal (21 females; 2 males). Two presented with concomitant pleural and peritoneal disease. There was one pericardial, and one testicular mesothelioma. The majority (51) were of the epithelioid histological subtype, followed by 13 biphasic, 8 sarcomatoid, 2 lymphohistiocytoid, and 1 poorly differentiated. Of the 11 individuals whose nontumorous tissues were analyzed for the presence of asbestiform fibers, all showed the presence of anthophyllite and/or tremolite asbestos. Conclusions Mesotheliomas can develop following exposures to cosmetic talcum powders. These appear to be attributable to the presence of anthophyllite and tremolite contaminants in cosmetic talcum powder.
- Subjects :
- medicine.medical_specialty
peritoneal
engineering.material
Talc
medicine.disease_cause
Asbestos
Tremolite Asbestos
pleural
medicine
Mesothelioma
Research Articles
business.industry
talc
Public Health, Environmental and Occupational Health
females
medicine.disease
Dermatology
tremolite
respiratory tract diseases
Anthophyllite
Concomitant
mesothelioma
engineering
Testicular mesothelioma
anthophyllite
Tremolite
business
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 10970274 and 02713586
- Volume :
- 63
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American Journal of Industrial Medicine
- Accession number :
- edsair.doi.dedup.....8bc231a46102c9235b07f1384a08ca69