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A G protein-coupled receptor for UDP-glucose
- Source :
- The Journal of biological chemistry. 275(15)
- Publication Year :
- 2001
-
Abstract
- Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP-glucose may possess pharmacological activity, suggesting that a receptor for this molecule may exist. Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells. Nucleotides known to activate P2Y receptors were inactive, indicating the distinctly novel pharmacology of this receptor. The receptor is expressed in a wide variety of human tissues, including many regions of the brain. These data suggest that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism.
- Subjects :
- Uridine Diphosphate Glucose
G protein-coupled receptor kinase
P2Y receptor
Receptors, Cell Surface
Cell Biology
Biology
Biochemistry
Neuron-derived orphan receptor 1
Cell biology
Radioligand Assay
GTP-Binding Proteins
ROR1
Humans
5-HT5A receptor
Molecular Biology
Protease-activated receptor 2
Nuclear receptor co-repressor 1
Phylogeny
G protein-coupled receptor
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 275
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- The Journal of biological chemistry
- Accession number :
- edsair.doi.dedup.....8bbd9f8b03890fe0a23d00a07904ad2a